1. Licensing: It is important to obtain the necessary licenses and permits required by the jurisdiction in which the online gambling business is operating.

2. Compliance: The business must comply with all laws and regulations concerning online gambling.

3. Player Protection: The business must ensure that their customers’ personal and financial information is protected and that there are measures in place to prevent problem gambling.

4. Responsible Gambling Policies: It is important to have responsible gambling policies to prevent people from spending more than they can afford and to promote safer gambling practices.

5. Payment processing: The business must ensure that payment processing is handled securely and that there are measures in place to prevent fraud.

6. Advertising and marketing: Online gambling businesses must comply with advertising and marketing regulations.

7. Anti-Money Laundering: The business must implement measures to prevent money laundering.

8. Customer support: The business must provide adequate customer support to its customers.

9. Taxation: The business must comply with tax laws and regulations.

10. Jurisdictional Restrictions: The business must ensure that they are not operating in jurisdictions where online gambling is prohibited.